- Diversity stability and resilience of the human gut microbiota Nov 23, 2024 · As discussed above bacterial diversity in the human gut exists within an individual 58, between individuals 59, and between different populations. Nature. , 2015) and human intervention studies have revealed that dietary fiber and whole grain intake increase the diversity of the gut microbiota (Martinez et al. Even basic questions about the diversity of the gut microbiota remained unanswered until the recent advent of higher-throughput sequencing: How much diversity exists in the human microbiota and microbiome (the collection of genes represented in the microbiota) at the species level and at higher taxonomic levels? Sep 1, 2012 · Microbial diversity in the healthy gut. , 2013; Tap et al. A. showcase the extensive genetic diversity of the human gut microbiota and its implications for the host. 1038/nature11550 PMID (DOI: 10. Fibers with multiple structures and composition can also be used to increase microbiota diversity, a characteristic of the microbiota that may be associated with resilience. The gut microbiota protects against enteropatho - gens1,2, extracts nutrients and energy from our diets 3,4, and Jun 19, 2017 · The long-term stability of the human gut microbiota. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. Gordon 2, Janet K. 2012 Sep 13; 489(7415):220-230. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease in microbial diversity of the Human gut. Maintaining our gut microbial lawn. . Fig. Thus, health is also a reflection of the diversity and composition of gut microbiota and its metabolic status. However, the microbiome as a whole is part of a The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time — especially during disease and early development. In defining host health, it remains unclear whether diversity is paramount, or whether greater weight is held by gut microbiota composition or mono- or multiple-functional capacity of the Diversity, stability and resilience of the human gut microbiota Catherine A. Microbial diversity Sep 14, 2020 · Studies of humans in different geographical locations showed that greater dietary fiber intake is associated with increased gut microbiota diversity (Rampelli et al. Even basic questions about the diversity of the gut microbiota remained unanswered until the recent advent of higher-throughput sequencing: How much diversity exists in the human microbiota and microbiome (the collection of genes represented in the microbiota) at the species level and at higher taxonomic levels? Dive into the research topics of 'Diversity, stability and resilience of the human gut microbiota'. Their insights into microbial evolution open avenues for targeted microbiota interventions. In defining host health, it remains unclear whether diversity is paramount, or whether greater weight is held by gut microbiota composition or mono- or multiple-functional capacity of the different taxa and the mechanisms involved. We finally discuss some open questions and knowledge gaps. 1. Even basic questions about the diversity of the gut microbiota remained unanswered until the recent advent of higher-throughput sequencing: How much diversity exists in the human microbiota and microbiome (the collection of genes represented in the microbiota) at the species level and at higher taxonomic levels? Sep 13, 2012 · The stability of the ecosystem in which gut microbiota is embedded is thought to increase with its diversity, which is usually assessed using two ecological indices-alpha diversity and beta Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Diversity, stability and resilience of the human gut microbiota Catherine A. From birth, neonates are exposed to microbes from a variety of sources, and the initial colonisation of their guts depends on the microbes first encountered. Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments. Jun 20, 2014 · Diversity, stability and resilience of the human gut microbiota. A scientific article Stability, resistance and resilience of the human gut microbiome Stability, resistance and resilience are essential ecological charac-teristics of the gut microbiome, given its importance for human health. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that May 1, 2016 · Thus, health is also a reflection of the diversity and composition of gut microbiota and its metabolic status. Sep 12, 2012 · The findings show that mice containing a sequenced model human gut microbiome can serve as part of a preclinical discovery pipeline designed to identify the effects of existing or new bacterial species with purported health benefits on the gut microbiomes of various human populations. Mar 17, 2016 · The microbiota should be considered as just another component of the human epigenetic landscape. 1038/NATURE11550) Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Stombaugh 1, Jeffrey I. Gut Microbiota Keyphrases 100% Sep 1, 2012 · Journal Article: Diversity, stability, and resilience of the human gut microbiota Diversity, stability, and resilience of the human gut microbiota Journal Article · Sat Sep 01 00:00:00 EDT 2012 · Nature Sep 1, 2012 · Microbial diversity in the healthy gut. Microbial diversity in the healthy gut. However, May’s work focused on networks where the types of interactions between species are randomly distributed, meaning that +/+ (cooperation) and –/– (competition) interactions occur with half the probability of +/– (exploitation) interactions. The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time — especially during disease and early development. In this review, we summarize recent progress towards characterizing the diversity and function of microbial communities in the healthy human gut, describe ways in which this ecosystem can go awry, and discuss prospects for ecosystem restoration. Sep 13, 2012 · The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time - especially during disease and early development. The human gut microbiota is seeded during birth and mainly develops over the first 3 years of life (24). Science 341 , 1237439 (2013). Sep 1, 2012 · The gut microbiota, the trillions of microbes inhabiting the human intestine, is a complex ecological community that through its collective metabolic activities and host interactions, influences both normal physiology and disease susceptibilities. https://doi. Microbial diversity, metabolic flexibility, functional redundancy, microbe-microbe and host-microbe interactions seem to be critical for maintaining resilience. Sep 12, 2012 · This paper gives insight into the resilience of the human microbiota in the face of repeated disturbances, and the degree of baseline variation. The gut microbiota protects against enteropatho - gens1,2, extracts nutrients and energy from our diets 3,4, and Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. Article CAS PubMed PubMed Central Google Scholar Nov 6, 2015 · Seminal work by May suggests that species diversity can be problematic for community stability (17, 19). Oct 9, 2024 · Shoer et al. , 2015 Dysbiosis, or imbalance of the microbiome, may have diverse compositional and functional attributes in different disease contexts []. This goal is The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. In many different diseases, however, the dysbiotic gut microbiome has been described to have a reduction in the proportion of anaerobes that are typically abundant in health and an increased proportion of facultative anaerobes, including Proteobacteria and Bacilli. 23 In the absence of a perturbation, the gut microbial community oscillates around a stable ecological state, showing a dynamic equilibrium Variability of the human gut microbiome across populations and over time. In this review, we focus on stability and resilience as essential ecological characteristics of the gut microbiome and its relevance for human health. Lozupone 1, Jesse I. org/10. Much has been described in the past decade based primarily on 16S rRNA gene amplicon sequencing regarding the diversity, structure, stability and dynamics of human microbiota in their various body habitats, most notably within the gastrointestinal tract (GIT). They find high strain-level variability associates with species’ capacity to sporulate, while low variability associates with carrying antibiotic resistance genes. Together they form a unique fingerprint. Jansson 3,4 & Rob Knight 1,5,6 M ost gut microbes are either harmless or of benefit to the host. Author(s): Lozupone, C. Lozupone CA et al. chhwwry kxrjv rxecws kkq ratp vqu fzc pyv eogckeqd idye